IGF-1 LR3

IGF-1LR3 Mechano Growth hormone Factor is the hottest buzz word in the bodybuilding community right now; as much as or more so than IGF of the late 1990s, and then again with the LR3 variant in the early 2000s. So what is Mechano Growth Factor or MGF as it is commonly called? If you do a quick search on some of the many bodybuilding web boards you will see a host of information, some of it correct,but most of it incorrect. MGF is part of the muscle insulin-like growth factor-I (IGF-I) mRNA splice variant IGF-IEc. It was first isolated and identified in rodents. IGF-IEc is more commonly called hormone Mechano Growth Factor, and has been found to be up-regulated by exercise or muscle damage.Growth hormone (GH) is the principal regulator of IGF-I expression in several tissues including skeletal muscle. MGF is derived from IGF-I, but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle. IGF